Mikroesfera-kontzentrazioaren analisia gibeleko erradioenbolizazioan "computational fluid dynamics" simulazioak erabiliz
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Gibeleko minbizia minbizi-moten artean hirugarren hilgarriena izan zen 2020an. Azken urteotan, erradioenbolizazioa, gibeleko arterian kokatutako kateter baten bidez mikroesfera erradioaktiboak injektatuz gauzatzen den tratamendua, ordenagailu bidezko odol-fluxuaren simulazioen bidez aztertu da. Ikerketa-lan honetan, orain arte ikertu gabe zegoen gai bat aztertzen zen: injekzio-abiaduraren eragina odoleko mikroesfera-kontzentrazioan. Hiru simulazio egin ziren eta emaitzek erakutsi zuten mikroesfera-kontzentrazioaren kurban, denboran zehar, injekzio-abiadurak ez duela eragin handirik, baina bai kurba horren anplitudean. Honi esker, gertuago egon gaitezke tratamendua paziente bakoitzaren beharretara egokitzeko bidean.
Liver cancer was the third leading cause of cancer-related deaths in 2020. In the last years, radioembolization, an intraarterial transcatheter treatment, has been studied using computational fluid dynamics. In this work, the authors study the influence of the injection velocity on the microsphere concentration in blood. Three simulations were run and results showed that the shape of the curve of the temporal microsphere concentration in blood is independent of the injection velocity, but the amplitude of the curve depends of the injection velocity. This may allow us to be closer to designing patient-specific treatments.
Liver cancer was the third leading cause of cancer-related deaths in 2020. In the last years, radioembolization, an intraarterial transcatheter treatment, has been studied using computational fluid dynamics. In this work, the authors study the influence of the injection velocity on the microsphere concentration in blood. Three simulations were run and results showed that the shape of the curve of the temporal microsphere concentration in blood is independent of the injection velocity, but the amplitude of the curve depends of the injection velocity. This may allow us to be closer to designing patient-specific treatments.
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erradioenbolizazioa, hemodinamika, CFD, mikroesfera-kontzentrazioa., radioembolization, hemodynamics, CFD, microsphere concentration.