Adenilato ziklasa toxinak bakterioen barneratzea eragiten du zelula ez-fagozitikoetan
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Bordetella pertussis kukutxeztula deituriko arnas-aparatuko gaixotasunaren eragilea da. Prebentziorako txertoa egon arren, munduan umeen heriotza gehien eragiten duen bosgarren gaixotasuna da. Historikoki patogeno extrazelularra dela pentsatu den arren, bakterio hau in vitro eta in vivo zelula fagozitiko eta ez-fagozitikoen barnean ikusi da. Hala ere, bakterioak zelula barnean sartzeko erabiltzen dituen mekanismoak eta bere birulentzia fakoreetatik zeinek duen eginkizun hori ez da oraindik ezagutzen. Lan honetan aurkitu dugu Adenilato Ziklasa toxina (ACT) , B. pertussis-en birulentzia faktore garrantzitsuenetako bat, nahikoa dela bakterioaren barneraketa eragiteko zelula ez-fagozitikoetan.
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium has been detected both in vitro and in vivo inside phagocytic and non-phagocytic cells. However the precise mechanism used by B. pertussis for cell entry, or the putative bacterial factors involved remain largely unknown. Here we find that adenylate cyclase toxin (ACT), one of the important toxins of B. pertussis, is sufficient to promote bacterial internalization into nonphagocytic cells.
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium has been detected both in vitro and in vivo inside phagocytic and non-phagocytic cells. However the precise mechanism used by B. pertussis for cell entry, or the putative bacterial factors involved remain largely unknown. Here we find that adenylate cyclase toxin (ACT), one of the important toxins of B. pertussis, is sufficient to promote bacterial internalization into nonphagocytic cells.