San Román Martinez, AnneAbilleira Cillero, EunateIrizar Loibide, AmaiaGonzález Gaya, BelénEtxebarria Loizate, Nestor2024-11-272024-11-27production.46829https://dx.doi.org/10.26876/ikergazte.v.05.15https://gordailua.ueu.eus/handle/123456789/2723Konposatu per- eta polifluoroalkilikoak (PFAS) karbono erabat fluoratua eta buru hidrofilo bat duten konposatu sintetikoak dira, 40ko hamarkadatik oso erabiliak izan dira kontsumo-ondasun anitzetan. Beren ezaugarri anfipatikoengatik, ia populazio guztiaren odol edo gernuan aurkitu ohi dira, dieta eta edateko ura izanik esposizio-iturri nagusiak. Milaka PFAS existitu arren, gutxi batzuk monitorizatu ohi dira, haiekiko esposizioa gutxietsi daitekeela iradokiz. Bestalde, maila subhilgarriekiko esposizio kronikoak umeetan osasun-arazoak eragin ditzake, hala nola, disrupzio endokrinoa edo ikasteko desgaitasuna. Hortaz, lan honen helburua PFAS espektro zabala kuantifikatzea da, Gipuzkoako 4 eta 8 urteko haurren plasman. Lortutako behin-behineko emaitzetan (n=450) denetariko PFASak topatu dira, kontzentrazio ezberdinetan, eta sexu eta adinaren arabera aldakorrak.Per- and polyfluoroalkyl compounds (PFASs) are synthetic compounds featured by at least one fully fluorinated carbon attached to a hydrophilic head, that have been widely used since the 1940s in a variety of consumer goods. Due to their amphipathic behavior, they are commonly found in the blood or urine of almost all population, being diet and drinking water the main sources of exposure. Although thousands of PFAS exist, only a few are monitored, suggesting that exposure can be underestimated. On the other hand, chronic exposure to sublethal levels can cause health problems in children, such as endocrine disruption or learning disability. Thus, the aim of this work is to quantify a broad spectrum of PFAS in 4- and 8-years children’s plasma samples from Gipuzkoa. Preliminaryresults (n=450) have shown presence of PFAS from different families at different concentrations, varying according to sex and age.PFASLC-HRMShaurrakplasma.PFASLC-HRMSchildrenplasma.HaurrakKimikaOsasunaintroduction