Fernandez Martinez, XabierAmuategi Aulestiarte, JoneGonzalez Bullón, DavidB. Uribe, KepaOstolaza Etxabe, Elena2024-11-272024-11-27production.42626https://dx.doi.org/10.26876/ikergazte.iii.05.18https://gordailua.ueu.eus/handle/123456789/2456Arnasbideetako infekzioek heriotza tasa altuak eragiten dituzte munduan. Infekziorik kutsakorrenen artean dagoBordetella pertussis bakterio patogenoak eragindako kukutxeztula. B. pertussisek jariatzen dituen birulentziafaktoreen artean arriskutsuenetako bat da Adenilato Ziklasa Toxina (ACT). Informazio asko bildu den arren,oraindik ez da zehazki deskribatu zelula ostalaria erasotzeko erabiltzen duen mekanismo molekularra. Ikerketahonetan, toxina eta mintzaren arteko elkarrekintzan lipido konposizioak daukan eragina aztertu da. Eskuratutakoemaitzetatik kolesterolak toxinaren aktibitatean eragin zuzena duela dela ondorioztatu da.Infectious respiratory diseases are among the main death causes in humans worldwide. The bacterial pathogenBordetella pertussis causes whooping cough, a highly contagious respiratory disease that remains an importantcause of childhood morbidity and mortality. Adenylate Cyclase Toxin (ACT) is one of the important virulencefactors secreted by this bacterium and has a crucial role in the early steps of colonization of the respiratory tractby the bacterium. The molecular mechanisms used by ACT to intoxicate the host cells are still poorly understood.In the present study we explored the effect of the lipid composition in the toxin interaction with lipid membranes.We conclude that ACT shows preference for the membrane cholesterol.Bordetella pertussisadenilato ziklasa toxinakolesterolaliposomakBordetella pertussisAdenylate Cyclase ToxincholesterolliposomesKimikaNatur ZientziakTerapeutikaintroduction