Depresioaren teoria noradrenergikoa

Abstract

Depresioren sintomatologia konplexua eta heterogeneoa da, diagnostikoa zailago bihurtuz. Depresioaren teoria eta faktore eragile desberdinak proposatu dira azken urteetan zehar. Hauen artean frogatu da tratamendu antidepresibo kroniko baten ostean neurona noradrenergikoetan kokatzen diren k desentsibilizazio prozesua jasaten dutela, monoaminen mailak modulatuz. Egun, ikertzeke dago neurona serotoninergikoetan espresatzen diren α2-adrenohartzaileen, hau da, heterohartzaileen, desentsibilizazioa gertatzen den ala ez. Lan honetan tratamendu antidepresibo kronikoaren ostean α2-heterohartzaileen desentsibilizazioa gertatzen den ala ez aztertu da, arratoi garunean egindako in vivo mikrodialisi teknikaren bitartez.

The symptomatology of depression is complex and heterogeneous, making diagnosis more difficult. Different theories and factors of depression have been proposed over the last few years. Among these, it has been shown that after a chronic treatment of antidepressants the α2- adrenoreceptor that control the levels of noradrenaline undergo desensitization, modulating the levels of monoamines. It remains to be investigated whether the adrenoreceptors found in serotonergic neurons expressed as heteroreceptor suffer desensitization. The objective of this work was to study whether the heteroreceptor suffers desensitization or not after chronic depressant treatment using an in vivo microdialysis technique.