Epe luzerako ondorioak loki-lobuluko epilepsia sagu-eredu baten garunean

Abstract

Loki-lobuluko epilepsia helduetan ematen den epilepsia mota ohikoena da. Eskuragarri dauden farmakoek neuronen gehiegizko kitzikagarritasuna murrizten duten arren, beti ez dira eraginkorrak izaten. Gaur egungo ikerketak gaitzean aktibatutako mekanismo neuroinflamatorioen kontrolean oinarritzen dira. Hartara, garuneko zelula ez neuronalak eta sistema endokannabinoidea itu terapeutiko gisa proposatu dira. Izan ere, neuroinflamazioarekin erlazionaturik dauden glia zelulek kannabinoide hartzaileak adierazten dituzte. Ikerketa honetan, glia zelula eta kannabinoide sisteman gertatutako aldaketak eta burmuinean zehar erasandako eskualdeak aztertu dira loki-lobuluko epilepsia sagu ereduan. Era ohargarrian, aldaketa anatomiko hauek kognizio (oroimenean) eta emozio-egoeretan (antsietatea) eragina dute.

Temporal lobe epilepsy is the most common type of epilepsy in adults. Although available anticonvulsants reduce the excessive neuronal excitability, they are not always effective. Nowadays research focuses on the control of neuroinflammatory mechanisms switched on in epilepsy. Hence, non-neuronal brain cells and the endocannabinoid system have emerged as potential targets because the role of this system in neuroinflammation mediated by cannabinoid receptor-expressing glial cells. We show changes in glial cells and the cannabinoid 1 (CB1) receptor, the main target of endogenous and exogenous cannabinoids, throughout brain regions in a mouse model of temporal lobe epilepsy. Remarkably, these anatomical changes impact on cognition (memory) and behavioral states (anxiety).