Nanopartikulen lipido konposizioak rHDLen kolesterol kanpora-fluxuaren efizientzian eragina du

Abstract

Aterosklerosia arteria nagusien intiman gertatzen den kolesterol metaketaren ondorioz garatzen da. Horren garrantzi klinikoa nabaria da, izan ere, aterosklerosiaren konplikazioek gaixotasun kardiobaskularrak eragin ditzakete. Aterosklerosiaren tratamendu zuzenerako, HDL naturalak imitatzen duten hainbat nanopartikulen diseinua burutu izan da (rHDL), ateroma plakako soberazko kolesterola iraizteko helburuarekin, hainbat entsegu kliniko aurrera eraman direlarik. Ikerketa honen helburua, lipido konposizio desberdina duten rHDLek kolesterola zeluletatik jasotzeko duten efizientzia aztertzea izan da. Erabilitako lipido konposizioak DPPC, DPPC:Chol:LysoPC, DPPC:CE:LysoPC eta soja jatorridun fosfatidilkolinak izan dira.

Atherosclerosis is developed as result of the accumulation of cholesterol within the intima of large arteries. The clinical significance of this disease is relevant as its complication could lead cardiovascular diseases. Recently, the development of several nanoparticles that mimic natural HDLs (rHDL) have been carried out with the aim of excreting excess cholesterol from atheroma plaque, which have been tested in clinical trials. The aim of this study was to assess the cholesterol efflux efficiency of rHDLs with different lipid composition. Lipid compositions used in this study were: DPPC, DPPC:Chol:LysoPC, DPPC:CE:LysoPC and Soy-PC.