Ikusezina ikusgai bihurtzearen erronka: analisi bideratutik ez-bideratura jauzia bereizmen altuko masa espektrometriari esker

Abstract

Konposatu organikoek gure eguneroko bizitzan ezinbesteko garrantzia izan arren, horiekiko daukagun esposizioa kezkagarria da. Izan ere, euretariko asko kaltegarriak izan daitezke bai gizakiontzat zein ingurumenarentzat. Kimika analitikoaren ikuspuntutik, beharrezkoa da ahalik eta konposatu gehien detektatzeko metodoen garapena; hots, analisi bideratutik susmagarrien analisira eta analisi ez-bideratura igarotzea. Erronka horri aurre egin nahian, lan honetan hainbat matrizerako (giza- zein animalia-esnea eta arrain-muskulua) garatutako metodo analitikoak laburbiltzen dira, bereizmen altuko masa espektrometrian (HRMSan) oinarrituta. Susmagarrien analisiari esker, askotan jarraitzen ez diren konposatu organiko anitz identifikatzea posible izan da matrize bakoitzean.

Although organic compounds are extremely important in our daily lives, the level of exposure that we have towards them is concerning, as they may pose a serious threat to humans and environment. From an analytical chemistry point of view, the development of methods for the detection of as many compounds as possible is mandatory. That means that the transition from target analysis to suspect screening or non-target analysis is needed. To overcome this challenge, different methods based on high resolution mass spectrometry (HRMS) to detect organic compounds in several matrices (human and animal origin milk and fish muscle) are described in the present work. The performed suspect analysis enabled identifying a wide variety of non-monitored compounds in each matrix.