Endometriosia eta ezaugarri antropometriko eta menstrualak: oinarri genetiko amankomunaren bila

Abstract

Endometriosia kausa ezezaguneko gaixotasun ginekologiko ohikoenetariko bat da, funtzionalki aktiboa den endometrio-ehuna utero-barrunbetik kanpo haztean agertzen dena. Fenotipo ugarirekin erlazionatu da, hala nola neurri antropometrikoekin eta ezaugarri menstrualekin. Hala ere, azken horiek eta endometriosiak oinarri genetiko bera partekatzen duten ez da oraindik ezagutzen. Genetika amankomun hau aztertzeko, bi lagineko ausazkotze mendeldar (2SMR) analisia burutu genuen, GWAS ikerketetako datu publikoak erabiliz. Gure emaitzen arabera, pisu baxuak eta hilekoaren ziklo laburrek endometriosiarekin harreman genetikoa dute. Are gehiago, badirudi erlazio hau kausala izan litekeela.

Endometriosis, of unknown cause, is one of the most prevalent gynecological diseases, characterized by the presence of functionally active endometrial tissue outside the womb. It has been associated with many phenotypes, such as anthropometric and menstrual traits. However, whether these traits and endometriosis share common genetic roots is still undetermined. To investigate this, we performed a two-sample mendelian randomization (2SMR) analysis, using public data from GWAS studies. Our results showed a genetic link between low weight and shorts menstrual cycles and endometriosis. Furthermore, it seems that this relationship could be causal.