Fe3O4 nanopartikulen prestakuntza eta karakterizazioa, hipertermia magnetikoan aplikatzeko

Abstract

Morfologia, tamaina eta gainazal propietate desberdinak dituzten nanopartikula mangetikoen sintesiak arrakasta handia izan du azken urte hauetan, ez ordea euren erabilera medikuntza munduan. Nanosistema hauek gorputzarekin biobateragarritasun oso altua izan behar dute, prozesu kimikoen bidez lortzen zaila dena. Hori gutxi balitz, partikula-tamaina eta funtzionalizazioa nanosistemek aplikazio biomedikoan duten errendimenduarekin zuzenean lotuta dago, hipertermia magnetikoan batez ere. Hortaz, erronka hauen domeinuak nanopartikula magnetikokin erlazionatuta dagoen ezarpen eremu zabalean eragina izango luke. Lan honetan, hipertermia magnetikoan erabiliko diren nanopartikula magnetikoen sintesi eta karakterizazio bide desberdinak azalduko dira.

Although the improvements performed in producing magnetite nanoparticles by chemical methods with diverse morphologies, sizes and surface properties, the applications of these systems for clinical trials is not so developed. Additionally, the role of the particle size and its functionalization on the performance of some biomedical applications, in particular hyperthermia, requires additional studies from the experimental point of view. Moreover, the application of these systems in medicine demands a high degree of biocompatibility. The fulfillment of these challenges would provide key contributions in the application of magnetite nanoparticles. In this work the preparation and characterization of magnetic nanoparticles with different size and morphology, together with cytotoxicity assays, for their development in magnetic hyperthermia are presented.