Morfinak hipometilazio globala eragiten du mES zeluletan autoerregulazioa daukan demetilazio aktibo baten bidez

Abstract

Ingurumen-faktoreek osasun-arazoak edota gaixotasunak sortzen dituzte, baino hori nola ematen den ezezaguna da. Orain arteko ikerketa gehienek adierazi dutenez, eraldaketa epigenetikoek funtzio gakoa bete dezakete prozesu horretan, bien arteko lotura puntua izanik. Morfinak, esaterako, plazenta-hesia modu erraz batean zeharkatu dezake, eta, ondorioz, enbrioiaren ohiko garapenean nabarmen eragiten du; hodi neurala, kortex frontala eta bizkarrezur-muinaren garapenak ukituta geratzen dira, nerbio-sistemaren garapen egokia oztopatuz. Hortaz, DNAren metilazioa enbrioi-garapenean giltzarri den eraldaketa epigenetikoa dela aintzat hartuz, metilazioak morfinaren presentzian izan dezakeen eginkizuna argitzea da gure helburua nagusia, eta horretarako azken belaunaldiko teknikez baliatu gara.

Environmental factors cause health problems and/or disease, but how it occurs is unknown. Most of the research carried out so far has indicated that epigenetic transformations can play a key role in this process, being the point of connection between both. Morphine, for example, can easily cross the placenta, which significantly affects the normal development of the embryo, affecting the development of the neural tube, frontal cortex and spinal cord, making it difficult for the proper development of the nervous system. Therefore, considering that DNA methylation is a key epigenetic transformation in embryonic development, our objective is to clarify the role that methylation can play in the presence of morphine, for which we have resorted to state-of-the-art techniques.