Opioide-hartzaileen deskribapena eta kokapena saguen hozi-zelula maskulinoetan

Abstract

Hainbat ikerketen arabera barne-peptido opioideak (BPO) arren zelula mota ezberdinetan aurkitzen dira. Aurretik egindako ikerketek, hiru opioide-hartzaileak (mu, delta eta kappa) soilik arratoien testikuluetako Sertoli zeluletan eta giza espermatozoideetan deskribatu dituzte. Espermatozoideak transkribapen eta itzulpen mailan jarduerarik gabeko zelulak izanda, pentsa liteke espermatogenesian zehar, lehenagoko urratsetan, adierazi direla. Emaitza hauek opioide-hartzaileek espermatogenesian duten jarduera erakusteaz gain, sistema opioideak ugalkortasunean, ama zeluletan, epigenetikan, minbizian eta zahartzea bezalako prozesuetan duten ekarpena ulertzen lagun dezake.

Numerous studies have demonstrated the presence of endogen opioid peptides (EOPs) in different male cell types. Previous studies have described the three opioid receptors (mu, delta and kappa) in testicular rat Sertoli cells and in human spermatozoa. Because of spermatozoa are not active cells in transcription and in translation phase it could be thought that those opioid receptors have been expressed during the spermatogenesis. These results contribute to resolve several long-standing issues concerning the role of opioid receptors in spermatogenesis and provide new insight into the function of the opioid system in fertility, stem cells, epigenetics, cancer and ageing.