Nerabezaroko gehiegizko alkohol kontsumoaren kalte iraunkorrak C57BL/6J sagu eme helduetan

Abstract

Betekadan oinarritutako alkohol kontsumoa da gehien ematen dena nerabeen artean. Kontsumo mota honek epe motzeko zein luzeko kalteak dakartza, nerabezaroan garunak garapen prozesu konplexua pairatzen baitu. Ondorioz, epe luzeko narriadura kognitiboa, CB1 hartzaile zelularraren galera eta honen menpeko epe luzeko plastikotasunaren asaldura ematen dira ar helduetan egindako ikerketen arabera. Ikerketa batzuen arabera emakumeak zaurgarriagoak diren arren alkoholaren kalteen aurrean, oraindik argitzeke dago epe luzera zehazki zein ondorio dituen nerabezaroko gehiegizko alkohol kontsumoak.

Binge drinking is the most common pattern of excessive alcohol consumption among adolescents. This habit causes short- and long-term damage as the brain goes through a complex developmental process during adolescence. Consequently, adolescence binge-drinking causes long-term cognitive disruption, as well as cannabinoid CB1 receptor density and CB1 receptor-mediated long-term plasticity loss in adult male mice. Although several studies have demonstrated females might be more vulnerable to alcohol, the long lasting effects of adolescence binge drinking in adult females, however, remain unknown.